VISCUM ALBUM PLANT The mistletoe lectins in the herb are hypotensive,anti cytotoxic , and immune – stimulating . It causes improvement symptoms of chronic joint conditions, and significant lengthening of several times of cancer patients as well an improvement of quality of life. Indications and usage: The stem of the herb is used for its calming effect: in the treatment of mental and exhaustation: and as tranquilizer against nervous conditions such as agitation, anxiety, and increase excitability. Approved by commission E: TUMOR THERAPY RHEUMATAISM It is used for treating degenerative inflammation of joints and as palliative therapy for malignant tumors through non specific stimulation. Other uses include long term therapy for cases of mild high pressure and as atherosclerosis prophylactic. It also may used for high blood pressure , epilepsy , whooping cough , asthma , vertiginous attack , amenorrhea , diarrhea , chorea , nervous tachycardia and hysteria. The herb is used for joint pain, tendon and muscle pain, lumbago, back pain, vaginal bleeding during pregnancy and a Galatia. Contraindications: Protein oversensitivity, chronic progressive infections e.g., tuberculosis, and conditions of high fever Precautions and adverse reactions: No health hazards or side effects are known in conjunction with the proper administration of designated therapeutic dosages. The berries are said to have emetic and evacuant effects and to have caused the death of children. However unambiguous proof for these effects does not exist. The wheal formation and the elevation of body temperature are considered as signs of immune system stimulation and therefore as positive therapeutic effects. Daily dosage: The recommended dose daily dosage is 10 gm The dosage foe medicinal tea is 1 to 2 cups daily, EUROPEAN MISLETOE WINE dosage is 3 to 4 glasses daily. The mechanism of the viscum album plant action as anti cancer by the reactivation of the inactivated p53 gene but what that means the researchers has approved that the gene p 53 which is located on the shot arm of the chromosome no: 17 it is an inhibitor gene for tumor growth and it is doing its role as anti malignant tumors through a lot of many mechanism play a role in apoptosis, genomic stability, and inhibition of angiogenesis through several mechanism: 1-It can activate DNA repair proteins when DNA has sustained damage 2-It can induce growth arrest by holding the cell cycle at the G/S regulation point on DNA damage recognition 3- it holds the cell for long enough , the DNA repair proteins will have time to fix the damage and the cell will be allowed to continue the cell cycle)). It can initiate apoptosis, the programmed cell death, if DNA proves to be irreparable 4- When the human body exposed to hypoxia or stress injury the human body is going to activate the p 53 gene to stop the cell grow thing in the g1/s phase that give the time to proteins to repair DNA so it doesn't permit it to pass into the next stage of the cell division stages. If there is a mutation of one of the two inherited genes the persons will susceptible to cancer occurrence an usually it develops in the two life peaks and the mutation in these genes was found in most viewed malignant tumors. The viscum album plant fights cancers and tumors by inhibiting the growth of cancer and by stimulating a host mediated response. NATURAL KILLER cells are also promoted enhance the immune system .It is often used in conjunction with chemotherapy to increase cancer survival rates. The viscum album plant fights is being proposed as an inhibitor of HIV replication based on in vitro study. The viscum album plant fights has also demonstrated itself to activate interferon production .VISCUM ALBUM PLANT has also been found to regenerate damaged bone marrow, increase energy levels and offer pain relief in cancer patients.
MENTHA PIPERITA : IT IS USEFUL IN THE TREATMENT OF COMMON COLD, COUGH, BRONCHITIS, FEVER AND COLDS, INFLAMATION OF THE MOUTH AND PHARYNX, LIVER AND GALL BLADDER COMPLAINTS, DYSPEPTIC COMPLAINTS, TENDENCY TO INFECTION, anemia ,thrombocytopenia , platelet dysfunction Page number 580 in the PDR FOR HERBAL MEDICINE In a conclusion the viscum album plant useful in the treatment of the malignant tumors in general, but after the recent experiences by the medical researchers in the company labs in CANADA it has been discovered that the adding of the MINTA PIPRETA making the mixture more powerful and useful in the treatment of malignant tumors in general and hematological based origin as a special condition CA B11 the is a list of the malignant hematological and malignant tumors that can be treated by the mixture CA B 11 AML ACUTE MYELOID LEUKEMIA CML CHRONIC MYELOID LEUKEMIA LEUKEMIA ALL ACUTE LYMPHOCYTIC CLL CHRONIC LYMPHOCYTIC LEUKEMIA T BURKITS LYMPHOMA HODJKIN AND NON HODJKIN Waldenstrom’s Macroglobulinemia Multiple Myeloma Hairy Cell Leukemia Sarcomas
CA B11 the is a list of the malignant gastrointestinal malignant tumors that can be treated by the mixture CA B 11
Tumors: digestive system neoplasia GI tract Upper GI tract Esophagus Squamous cell carcinoma • Adenocarcinoma Stomach Gastric carcinoma • Signet ring cell carcinoma • Gastric lymphoma (MALT lymphoma) • Linitis plastica Lower GI tract Small intestine Duodenal cancer (Adenocarcinoma) Appendix Carcinoid • Pseudomyxoma peritonei Colon/rectum colorectal polyp: Peutz-Jeghers syndrome • Juvenile polyposis syndrome • Familial adenomatous polyposis/Gardner's syndrome • Cronkhite–Canada syndrome neoplasm: Adenocarcinoma • Familial adenomatous polyposis • Hereditary nonpolyposis colorectal cancer Anus Squamous cell carcinoma Upper and/or lower Gastrointestinal stromal tumor • Krukenberg tumor (metastatic) Accessory Liver malignant: Hepatocellular carcinoma (Fibrolamellar) • Hepatoblastoma benign: Hepatocellular adenoma • Cavernous hemangioma hyperplasia: Focal nodular hyperplasia • Nodular regenerative hyperplasia Biliary tract bile duct: Cholangiocarcinoma • Klatskin tumor gallbladder: Gallbladder cancer Pancreas exocrine pancreas: Adenocarcinoma • Pancreatic ductal carcinoma cystic neoplasms: Serous microcystic adenoma • Intraductal papillary mucinous neoplasm • Mucinous cystic neoplasm • Solid pseudopapillary neoplasm Pancreatoblastoma Peritoneum Primary peritoneal carcinoma • Peritoneal mesothelioma • Desmoplastic small round cell tumor
REFERENCES AGRAWAL, V. and SARDAR, P.R. In vitro propagation of Cassia angustifolia through leaflet and cotyledon derived calli. Biologia Plantarum, March 2006, vol. 50, no. 1, p. 118-122. ARAI, M.; SAITO, T.; KANEKO, Y. and MATSUSHIMA, H. Cellular origin and ultrastructural changes of regenerating shoots from tobacco (Nicotiana tabacum) Beegum, A.S. et al. 121 internodes cultured in vitro. Physiologia Plantarum, April 1997, vol. 99, no. 4, p. 523-528. BECKER, Y. and OLSHEVSKY, U. Inhibition of herpes simplex virus replication by camptothecin. Israel Journal of Medical Sciences, 1973, vol. 9, no. 11-12, p. 1578-1581. BODLEY, Annette L.; CUMMING, Jared N. and SHAPIRO, Theresa A. Effects of camptothecin, a topoisomerase I inhibitor, on Plasmodium falciparum. Biochemical Pharmacology, March 1998, vol. 55, no. 5, p. 709-711. CREEMERS-MOLENAAR, J.; HAKKERT, J.C.; VAN STAVEREN, M.J. and GILISSEN, L.J.W. Histology of the morphogenetic response in thin cell layer explants from vegetative tobacco plants. Annals of Botany, May 1994, vol. 73, no. 5, p. 547-555. DE PAIVA NETO, Vespasiano Borges; DA MOTA, Tiago Ribeiro and OTONI, Wagner Campos. Direct organogenesis from hypocotyl-derived explants of annatto (Bixa orellana). Plant Cell, Tissue and Organ Culture, November 2003, vol. 75, no. 2, p. 159-167. DENNIS, Thomas T. and BOBAN, Philip. Thidiazuroninduced high-frequency shoot organogenesis from leafderived callus of a medicinal climber, Tylophora indica (Furm. f.) Merrill. In Vitro Cellular and Development Biology - Plant, March-April 2005, vol. 41, no. 2, p. 124- 128. DHAR, Uppeandra and JOSHI, Mitali. Efficient plant regeneration protocol through callus for Saussurea obvallata (DC.) Edgew. (Asteraceae): effect of explant type, age and plant growth regulators. Plant Cell Reports, June 2005, vol. 24, no. 4, p. 195-200. FAISAL, M. and ANIS, M. An efficient in vitro method for mass propagation of Tylophora indica. Biologia Plantarum, June 2005, vol. 49, no. 2, p. 257-260. GIOVANELLA, B.C.; STEHLIN, J.S.; WALL, M.E.; WANI, M.C.; NICHOLAS, A.W.; LIU, L.F.; SILBER, R. and POTMESIL, M. DNA topoisomerase I-targeted chemotherapy of human colon cancer in xenografts. Science, November 1989, vol. 246, no. 4933, p. 1046-1048. JAPAN PHARMACEUTICAL INFORMATION CENTER. Drugs in Japan, Ethical Drugs. Yakugyo Jiho Co.; Tokyo, 1995, 169-270 p. JOSE, B. and SATHEESHKUMAR, K. In vitro mass multiplication of Ophiorrhiza mungo Linn. Indian Journal of Experimental Biology, June 2004, vol. 42, no. 6, p. 639- 642. KAWIAK, Anna; KROLICKA, Aleksandra and LOJKOWSKA, Ewa. Direct regeneration of Drosera from leaf explants and shoot tips. Plant Cell, Tissue and Organ Culture, November 2003, vol. 75, no. 2, p. 175-178. KIRTIKAR, K.R. and BASU, B.D. Indian Medicinal Plants Vol. II. 2 nd ed. M/S Bishen Singh Mahendrapal Singh, New Delhi, India, 1975. p. 1268-1269. KNOLL, K.A.; SHORT, K.C.; CURTIS, I.S.; POWER, J.B. and DAVEY, M.R. Shoot regeneration from cultured root explants of spinach (Spinacia oleracea L.): a system for Agrobacterium transformation. Plant Cell Reports, December 1997, vol. 17, no. 2, p. 96-101. LIAO, Zhihua; CHEN, Min; TAN, Feng; SUN, Xiaofen and TANG, Kexuan. Micropropagation of endangered Chinese aloe. Plant Cell, Tissue and Organ Culture, January 2004, vol. 76, no. 1, p. 83-86. LIU, Z. and LI, Z. Micropropagation of Camptotheca acuminata decaisne from axillary buds, shoot tips, and seed embryos in a tissue culture system. In Vitro Cellular and Development Biology - Plant, January 2001, vol. 37, no. 1, p. 84-88. LO, K.H.; GILES, K.L. and SAWHNEY, V.K. Histological changes associated with acquisition of competence for shoot regeneration in leaf discs of Saintpaulia ionantha X confusa hybrid (African violet) cultured in vitro. Plant Cell Reports, March 1997, vol. 16, no. 6, p. 421-425. LORENCE, Argelia and NESSLER, Craig L. Camptothecin, over four decades of surprising findings. Phytochemistry, October 2004, vol. 65, no. 20, p. 2735- 2749. LORENCE, Argelia; MEDINA-BOLIVAR, F. and NESSLER, Craig L. Camptothecin and 10- hydroxycamptothecin from Camptotheca acuminata hairy roots. Plant Cell Reports, January 2004, vol. 22, no. 6, p. 437-441. MARTIN, K.P. Rapid in vitro multiplication and ex vitro rooting of Rotula aquatica Lour., a rare rhoeophytic woody medicinal plant. Plant Cell Reports, January 2003a, vol. 21, no. 5, p. 415-420. MARTIN, K.P. Rapid axillary bud proliferation and ex vitro rooting of Eupatorium triplinerve. Biologia Plantarum, December 2003b, vol. 47, no. 4, p. 589-591. MARTIN, K.P.; JOSEPH, D.; MADASSERY, J. and PHILIP, V.J. Direct shoot regeneration from lamina explants of two commercial cut flower cultivars of Anthurium andraeanum Hort. In Vitro Cellular and Development Biology - Plant, September-October 2003, vol. 39, no. 5, p. 500-504. MARTIN, K.P.; SUNANDAKUMARI, C.; CHITHRA, M. and MADHUSOODANAN, P.V. Influence of auxins in direct in vitro morphogenesis of Euphorbia nivulia, a Rapid propagation of camptothecin producing plant, Ophiorrhiza prostrata 122 lectinacious medicinal plant. In Vitro Cellular and Development Biology - Plant, May-June 2005, vol. 41, no. 3, p. 314-319. MURASHIGE, T. and SKOOG, F. A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiologia Plantarum, October 1962, vol. 15, no. 43, p. 473-497. MURASHIGE, T. Plant propagation through tissue cultures. Annual Review of Plant Physiology, June 1974, vol. 25, p.135-166. PANTAZIS, Panayotis; HAN, Zhiyong; CHATTERJEE, Devasis and WYCHE, James. Water-insoluble camptothecin analogues as potential antiviral drugs. Journal of Biomedical Science, January 1999, vol. 6, no. 1, p. 1-7. PRIEL, E.; SHOWALTER, S.D. and BLAIR, D.G. Inhibition of human immunodeficiency virus (HIV-1) replication in vitro by noncytotoxic doses of camptothecin, a topoisomerase I inhibitor. AIDS Research and Human Retroviruses, 1991, vol. 7, no. 1, p. 65-72. PRUSKI, Kris; ASTATKIE, Tess and NOWAK, Jerzy. Tissue culture propagation of Mongolian cherry (Prunus fruticosa) and Nanking cherry (Prunus tomentosa). Plant Cell, Tissue and Organ Culture, August 2005, vol. 82, no. 2, p. 207-211. RAJASEKHARAN, K.; HEIN, M.B.; DAVIS, G.C.; CARNES, M.G. and VASIL, I.K. Endogenous growth regulators in leaves and tissue cultures of Pennisetum purpureum Schum. Journal of Plant Physiology, 1987, vol. 130, no. 1, p.13-25. REDINBO, Matthew R.; STYEWART, Lance; KUHN, Peter; CHAMPOUX, James J. and HOL, Wim G.J. Crystal structures of human topoisomerase I in covalent and monocovalent complexes with DNA. Science, March 1998, vol. 279, no. 5356, p. 1504-1513. ROJA, G. Comparative studies on the camptothecin content from Nothapodytes foetida and Ophiorrhiza species. Natural Product Research, January 2006, vol. 20, no. 1, p. 85-88. ROUT, Gyana Ranjan. Direct plant regeneration of curry leaf tree (Murraya koenigii Koenig.), an aromatic plant. In Vitro Cellular and Development Biology - Plant, MarchApril 2005, vol. 41, no. 2, p. 133-136. SAITO, K.; SUDO, H.; YAMAZAKI, M.; KOSEKINAKAMURA, M.; KITAJIMA, M.; TAKAYAMA, H. and AIMI, N. Feasible production of camptothecin by hairy root cultures of Ophiorrhiza pumila. Plant Cell Reports, March 2001, vol. 20, no. 3, p. 267-271. SHRIVASTAVA, N. and RAJANI, M. Multiple shoot regeneration and tissue culture studies on Bacopa monnieri (L.) Pennell. Plant Cell Reports, August 1999, vol. 18, no. 11, p. 919-923. SHU, Q.Y.; LIU, G.S.; QI, D.M.; CHU, C.C.; LIU, J. and LI, H.J. An effective method for axillary bud culture and RAPD analysis of cloned plants in tetraploid black locust. Plant Cell Reports, October 2003, vol. 22, no. 3, p. 175- 180. SIVARAM, Latha and MUKUNDAN, Usha. In vitro culture studies on Stevia rebaudiana. In Vitro Cellular and Development Biology - Plant, September-October 2003, vol. 39, no. 5, p. 520-523. ŠTAJNER, Nataša; BOHANEC, Borut and JAKŠE, Marijana. In vitro propagation of Asparagus maritimus - A rare Mediterranean salt-resistant species. Plant Cell, Tissue and Organ Culture, September 2002, vol. 70, no. 3, p. 269- 274. SUDO, Hiroshi; YAMAKAWA, Takashi; YAMAZAKI, Mami; AIMI, Norio and SAITO, Kazuki. Bioreactor production of camptothecin by hairy root cultures of Ophiorrhiza pumila. Biotechnology Letters, March 2002, vol. 24, no. 5, p. 359-363. SUNANDAKUMARI, C.; ZHANG, C.-L.; MARTIN, K.P.; SLATER, A. and MADHUSOODANAN, P.V. Effect of auxins on indirect in vitro morphogenesis and expression of gusA transgene in a lectinacious medicinal plant, Euphorbia nivulia Buch.-Ham. In Vitro Cellular and Development Biology - Plant, September-October 2005, vol. 41, no. 5, p. 695-699. TAFUR, S.; NELSON, J.D.; DELONG, D.C. and SVOBODA, G.H. Antiviral components of Ophiorrhiza mungos isolation of camptothecin and 10- methoxycamptothecin. Lloydia, 1976, vol. 39, no. 4, p. 261- 262. TAKEUCHI, S.; DOBASHI, K.; FUJIMOTO, S.; TANAKA, K.; SUZUKI, M.; TERASHIMA, Y.; HASUMI, K.; AKIYA, K.; NEGISHI, Y. and TAMAYA, T. A late phase II study of CPT-11 in gynecologic cancers. Research groups of CPT-11 in gynecologic cancers. Japanese Journal of Cancer and Chemotherapy, August 1991, vol. 18, no. 10, p. 1681-1689. TIWARI, V.; SINGH, B.D. and TIWARI, K. N. Shoot regeneration and somatic embryogenesis from different explants of Brahmi [Bacopa monniera (L.) Wettst.]. Plant Cell Reports, April 1998, vol. 17, no. 6-7, p. 538-543. TWYFORD, C.T. and MANTELL, S.H. Production of somatic embryos and plantlets from root cells of the greater yam. Plant Cell, Tissue and Organ Culture, July 1996, vol. 46, no. 1, p. 17-26.Beegum, A.S. et al. 123 WALL, M.E.; WANI, M.C.; COOK, C.E.; PALMER, K.H.; MCPHAIL, A.T. and SIM, G.A. Plant anti-tumor agents: I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata. Journal of the American Chemical Society, August 1966, vol. 88, no. 16, p. 3888- 3890. WATASE, I.; SUDO, H.; YAMAZAKI, M. and SAITO, K. Regeneration of transformed Ophiorrhiza pumila plants producing camptothecin. Plant Biotechnology, 2004, vol. 21, no. 5, p. 337-342. WELANDER, M. Plant regeneration from leaf and stem segments of shoots raised in vitro from mature apple trees. Journal of Plant Physiology, 1988, vol. 132, no. 6, p. 738- 744. WENZEL, C.L. and BROWN, D.C.W. Histological events leads to somatic embryo formation in cultured petioles of alfalfa. In Vitro Cellular and Development Biology - Plant, 1991, vol. 27, p. 190-196. ZHANG, Chun-Lai; CHEN, Dong-Fang; ELLIOTT, Malcolm C. and SLATER, Adrian. Thidiazuron-induced organogenesis and somatic embryogenesis in sugar beet (Beta vulgaris L). In Vitro Cellular and Development Biology - Plant, March 2001, vol. 37, no. 2, p. 305-310 the medical head office of the company DR.SALEH DABBAGH |